Hydrochloric Acid → N-(4-(((3S,5S)-3,5-Dimethylmorpholino)methyl)-2,5-difluorophenyl)-5-fluoro-4-(2-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)pyrimidin-2-amine hydrochloride

HRID 1924024노트

반응식

HRID 1924024 반응식
[CH3:1][C@@H:2]1[N:7]([CH2:8][C:9]2[C:14]([F:15])=[CH:13][C:12]([NH:16][C:17]3[N:22]=[C:21]([C:23]4[N:27]([CH:28]5[CH2:33][CH2:32][O:31][CH2:30][CH2:29]5)[C:26]([CH3:34])=[N:25][CH:24]=4)[C:20]([F:35])=[CH:19][N:18]=3)=[C:11]([F:36])[CH:10]=2)[C@@H:6]([CH3:37])[CH2:5][O:4][CH2:3]1.[ClH:38]>ClCCl>[ClH:38].[CH3:1][C@@H:2]1[N:7]([CH2:8][C:9]2[C:14]([F:15])=[CH:13][C:12]([NH:16][C:17]3[N:22]=[C:21]([C:23]4[N:27]([CH:28]5[CH2:33][CH2:32][O:31][CH2:30][CH2:29]5)[C:26]([CH3:34])=[N:25][CH:24]=4)[C:20]([F:35])=[CH:19][N:18]=3)=[C:11]([F:36])[CH:10]=2)[C@@H:6]([CH3:37])[CH2:5][O:4][CH2:3]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 49782014N-(4-(((3S,5S)-3,5-Dimethylmorpholino)methyl)-2,5-difluorophenyl)-5-fluoro-4-(2-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)pyrimidin-2-amine

생성물 1

HCID 49782252N-(4-(((3S,5S)-3,5-Dimethylmorpholino)methyl)-2,5-difluorophenyl)-5-fluoro-4-(2-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)pyrimidin-2-amine hydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

N-(4-(((3S,5S)-3,5-dimethylmorpholino)methyl)-2,5-difluorophenyl)-5-fluoro-4-(2-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)pyrimidin-2-amine (16 mg) was dissolved in dichloromethane (4 ml) and HCl (1M in diethyl ether, 0.05 ml) was added. The solvents were evaporated to give the title compound (0.015 g) as a solid.

후처리

  1. customThe solvents were evaporated

출처 및 근거

ORD 기록
ord-41addefe23d442708ddf864b4c61529d
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08178529B2

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