HCID 86631464, 화합물 → HCID 57743028, 화합물

HRID 1924229노트

반응식

HRID 1924229 반응식
Cl.[O:2]=[C:3]1[CH2:7][CH:6]([CH2:8][CH2:9][CH3:10])[CH2:5][N:4]1[CH2:11][C:12]1[N:16]([CH2:17][C:18]([O:20]CC)=[O:19])[CH:15]=[N:14][CH:13]=1>Cl>[O:2]=[C:3]1[CH2:7][CH:6]([CH2:8][CH2:9][CH3:10])[CH2:5][N:4]1[CH2:11][C:12]1[N:16]([CH2:17][C:18]([OH:20])=[O:19])[CH:15]=[N:14][CH:13]=1

참가 물질

3

반응물 1

HCID 86631464HCID 86631464, 화합물

생성물 1

HCID 57743028HCID 57743028, 화합물

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

반응 조건

온도
40 °C

실험 절차

In a 250 ml, three necked flask fitted with a magnetic stirrer, ethyl {5-[(2-oxo-4-propylpyrrolidin-1-yl)methyl]-1H-imidazol-1-yl}acetate hydrochloride x49 (5.19 g, 0.018 mol) is dissolved in 2M HCl (150 ml) and heated at 40° C. for 20 h. The reaction mixture is evaporated to dryness to afford the crude acid x50 (6.19 g) that is used as such in the next step.

후처리

  1. customIn a 250 ml, three necked flask fitted with a magnetic stirrer
  2. customThe reaction mixture is evaporated to dryness

출처 및 근거

ORD 기록
ord-ee5b79c74cb441b886587a4384ae640c
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08178533B2

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