Triethylamine hydrochloride → HCID 178506136, 화합물

HRID 1924428노트

반응식

HRID 1924428 반응식
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[C:5]#[N:6].[N-:13]=[N+:14]=[N-:15].[Na+].Cl.C(N(CC)CC)C>C1(C)C=CC=CC=1>[F:1][C:2]([F:11])([F:12])[C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[C:5]1[NH:15][N:14]=[N:13][N:6]=1

참가 물질

5

반응물 3

HCID 11130Triethylamine hydrochlorideHCID 33557Sodium AzideHCID 679722-(Trifluoromethyl)benzonitrile

생성물 1

HCID 178506136HCID 178506136, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
110 °C

실험 절차

A vigorously stirred suspension of 2-(trifluoromethyl)benzonitrile (2-A) (6.34 g, 37 mmol), sodium azide (4.81 g, 74 mmol) and triethylamine hydrochloride (10.19 g, 74 mmol) in toluene (70 mL) was heated at 110° C. for 48 h. The mixture was cooled and extracted twice with water. The combined extracts were washed with hexane and brought to pH about 1 with concentrated HCl. The precipitate which formed was filtered, washed with water and dried to give 5-[2-(trifluoromethyl)phenyl]-1H-tetrazole (2-B).

후처리

  1. temperatureThe mixture was cooled
  2. extractionextracted twice with water
  3. washThe combined extracts were washed with hexane
  4. customThe precipitate which formed
  5. filtrationwas filtered
  6. washwashed with water
  7. customdried

출처 및 근거

ORD 기록
ord-d4a4c10ce4dc490b844a1ab037243215
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08178546B2

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