Phenylacetyl chloride → N-(5-nitropyridin-2-yl)-2-phenylacetamide

HRID 1924971

반응식

HRID 1924971 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.[C:11]1([CH2:17][C:18](Cl)=[O:19])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>N1C=CC=CC=1.C1COCC1>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:18](=[O:19])[CH2:17][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:3][CH:4]=1)([O-:10])=[O:9]

참가 물질

5

반응물 2

HCID 7679Phenylacetyl chlorideHCID 778882-Amino-5-nitropyridine

생성물 1

HCID 4350143N-(5-nitropyridin-2-yl)-2-phenylacetamide

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 2-amino-5-nitropyridine (4.17 g, 30 mmol) in pyridine (30 mL) is stirred at rt and a solution of phenylacetyl chloride (4.64 g, 30 mmol) in THF (30 mL) is added dropwise. The mixture is stirred for 24 h and then poured into ice-water (250 mL) to afford a brown solid, which is used without further purification.

후처리

  1. customto afford a brown solid, which
  2. customis used without further purification

출처 및 근거

ORD 기록
ord-70c1396ac5d94286907f49fd6b84f93b
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08178530B2

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