2,4-Bis(methyloxy)-5-(4-methyl-1,3-thiazol-2-yl)pyrimidine → 5-(4-methyl-1,3-thiazol-2-yl)-2,4(1H,3H)-pyrimidinedione
반응식
C[O:2][C:3]1[N:8]=[C:7]([O:9]C)[C:6]([C:11]2[S:12][CH:13]=[C:14]([CH3:16])[N:15]=2)=[CH:5][N:4]=1>Cl.O1CCOCC1>[CH3:16][C:14]1[N:15]=[C:11]([C:6]2[C:7](=[O:9])[NH:8][C:3](=[O:2])[NH:4][CH:5]=2)[S:12][CH:13]=1참가 물질
4
반응 조건
- 온도
- 90 °C
실험 절차
2,4-bis(methyloxy)-5-(4-methyl-1,3-thiazol-2-yl)pyrimidine (Prep40, 280 mg, 0.861 mmol) was dissolved in 18 mL of hydrochloric acid 4M in dioxane and the resulting mixture was stirred in a round bottomed flask at 90° C. for 2 hours. Then it was cooled to rt and dried under vacuum to afford the title compound as a yellow solid (300 mg, 0.760 mmol)
후처리
- temperatureThen it was cooled to rt
- customdried under vacuum
출처 및 근거
- ORD 기록
- ord-94e95d24e6f843b79c08b737dba71578
- 출처 데이터셋
- uspto-grants-2012_05
- 특허 번호
- US08178549B2
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