Hydrochloric Acid → 1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-5-[3-(trifluoromethyl)-1H-pyrazol-1-yl]-2,4(1H,3H)-pyrimidinedione dihydrochloride

HRID 1925053노트

반응식

HRID 1925053 반응식
[F:1][C:2]([F:36])([F:35])[C:3]1[CH:8]=[CH:7][C:6]([C@:9]23[CH2:14][C@H:13]2[CH2:12][N:11]([CH2:15][CH2:16][CH2:17][N:18]2[CH:23]=[C:22]([N:24]4[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[N:25]4)[C:21](=[O:33])[NH:20][C:19]2=[O:34])[CH2:10]3)=[CH:5][CH:4]=1.[ClH:37]>C(OCC)C>[ClH:37].[ClH:37].[F:36][C:2]([F:1])([F:35])[C:3]1[CH:4]=[CH:5][C:6]([C@:9]23[CH2:14][C@H:13]2[CH2:12][N:11]([CH2:15][CH2:16][CH2:17][N:18]2[CH:23]=[C:22]([N:24]4[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[N:25]4)[C:21](=[O:33])[NH:20][C:19]2=[O:34])[CH2:10]3)=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 252531381-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-5-[3-(trifluoromethyl)-1H-pyrazol-1-yl]-2,4(1H,3H)-pyrimidinedione

생성물 1

HCID 866443941-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-5-[3-(trifluoromethyl)-1H-pyrazol-1-yl]-2,4(1H,3H)-pyrimidinedione dihydrochloride

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-5-[3-(trifluoromethyl)-1H-pyrazol-1-yl]-2,4(1H,3H)-pyrimidinedione (E20, 10.3 mg, 0.020 mmol) was dissolved in Diethyl ether (2 ml). 1M solution of HCl in Diethyl ether (0.044 ml, 0.044 mmol) was added. The solvent was evaporated to obtain 11.6 mg of the title compound as a yellow powder.

후처리

  1. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-250f9fc8a58c45ffaffca7a4f1d89103
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08178549B2

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