Hydrazine hydrate (1:1) → 2-(6-Hydrazinylpyridin-3-yl)propan-2-ol

반응식

Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]([OH:11])([CH3:10])[CH3:9])=[CH:4][CH:3]=1.O.[NH2:13][NH2:14]>>[NH:13]([C:2]1[N:7]=[CH:6][C:5]([C:8]([OH:11])([CH3:10])[CH3:9])=[CH:4][CH:3]=1)[NH2:14]

참가 물질

반응물 2

HCID 24654Hydrazine hydrate (1:1)

HCID 125621182-(6-Chloropyridin-3-yl)propan-2-ol

생성물 1

HCID 552817922-(6-Hydrazinylpyridin-3-yl)propan-2-ol

반응 조건

온도: 110 °C

실험 절차

A mixture of 2-(6-chloropyridin-3-yl)propan-2-ol (975 mg, 5.68 mmol), and hydrazine hydrate (5512 μl, 114 mmol) was heated in a microwave on high absorbance for 10 hr at 110° C. The mixture was cooled to room temperature and the hydrazine was removed via rotary evaporation. The resulting yellow residue was used without further work-up.

후처리

temperatureThe mixture was cooled to room temperature
customthe hydrazine was removed via rotary evaporation

출처 및 근거

ORD 기록: ord-27ccae116e6240efa30b94b759b11845
출처 데이터셋: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08178534B2

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