Trifluoroacetic acid → HCID 67520244, 화합물

HRID 1925370노트

반응식

HRID 1925370 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[C:23]([C:27]([O:29][CH3:30])=[O:28])=[CH:22][CH:21]=[CH:20]2.C(O)(C(F)(F)F)=O.[OH-].[Na+]>O.C(O)(C)C>[CH3:13][O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[O:14][CH3:15])[N:5]=[CH:4][N:3]=[C:2]2[NH:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[C:23]([C:27]([O:29][CH3:30])=[O:28])=[CH:22][CH:21]=[CH:20]2

참가 물질

7

반응물 4

HCID 6422Trifluoroacetic acidHCID 14798Sodium HydroxideHCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 24823732Methyl 6-aminonaphthalene-1-carboxylate

생성물 1

HCID 67520244HCID 67520244, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 3776Isopropanol용매

반응 조건

온도
90 °C

실험 절차

The following reagents were combined in a flask and placed in a RT oil bath that was then heated to 90° C.: 4-Chloro-6,7-dimethoxyquinazoline (954 mg, 4.24 mmol), methyl 6-amino-1-naphthoate (857 mg, 4.24 mmol), TFA (098 mL, 12.7 mmol), and isopropanol (12 mL). The reaction was done before the bath reached the desired temperature. The mixture was diluted with water and made pH basic with 6N NaOH. The solid was filtered and rinsed with water and Et2O. The title compound was obtained as a pink solid.

후처리

  1. customThe following reagents were combined in a flask
  2. customplaced in a RT
  3. filtrationThe solid was filtered
  4. washrinsed with water and Et2O

출처 및 근거

ORD 기록
ord-edb471c15f0748b295fbd310e88be657
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08178557B2

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