Water → 3-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)-5-(trifluoromethyl)benzenamine

HRID 1925391노트

반응식

HRID 1925391 반응식
[H-].[H-].[H-].[H-].[Li+].[Al+3].[NH2:7][C:8]1[CH:9]=[C:10]([C:18]2[CH2:23][CH2:22][N:21]([C:24](OC(C)(C)C)=O)[CH2:20][CH:19]=2)[CH:11]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:13]=1.O.[OH-].[Na+]>C1COCC1>[CH3:24][N:21]1[CH2:20][CH:19]=[C:18]([C:10]2[CH:9]=[C:8]([NH2:7])[CH:13]=[C:12]([C:14]([F:15])([F:16])[F:17])[CH:11]=2)[CH2:23][CH2:22]1

참가 물질

6

반응물 4

HCID 962Water2회HCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydride2회HCID 67520234tert-butyl 4-(3-amino-5-(trifluoromethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate

생성물 1

HCID 219596433-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)-5-(trifluoromethyl)benzenamine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

Into a 100 mL round bottom flask was placed LAH (1.518 g, 40 mmol) and suspended in THF (30 mL). Flask placed into an ice bath. Tert-butyl 4-(3-amino-5-(trifluoromethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate (1.368 g, 4 mmol) is added to THF (10 mL) and this solution is in turn added dropwise to the LAH suspension at 0° C. 15 min after addition was complete, flask is equipped with reflux condensor and allowed to reflux 15 h with stirring. Work up: Water (1.5 g) is added dropwise, then 15% NaOH(aq)(w/w)(1.5 g), followed by water (3 g). White precipitate forms after 20 h of stirring, filtered solids, removed solvent under reduced pressure. No further purification done. LC-MS (+) shows mass 257 (M+H), as expected for C13H15F3N2, mw 256.27.

후처리

  1. customInto a 100 mL round bottom flask was placed
  2. customFlask placed into an ice bath
  3. addition15 min after addition
  4. customflask is equipped
  5. temperaturewith reflux condensor
  6. temperatureto reflux 15 h
  7. stirringWhite precipitate forms after 20 h of stirring
  8. filtrationfiltered solids
  9. customremoved solvent under reduced pressure
  10. customNo further purification

출처 및 근거

ORD 기록
ord-c99e2c9b9c534901bfd73613baa6588f
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08178557B2

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