Tert-butyl (2-{4-[2-(1-adamantyl)ethoxy]phenyl}ethyl)-carbamate → (2-{4-[2-(1-Adamantyl)ethoxy]phenyl}ethyl)amine

HRID 1925496노트

반응식

HRID 1925496 반응식
[C:1]12([CH2:11][CH2:12][O:13][C:14]3[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH:22]C(=O)OC(C)(C)C)=[CH:16][CH:15]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2>Cl.CO>[C:1]12([CH2:11][CH2:12][O:13][C:14]3[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH2:22])=[CH:16][CH:15]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

참가 물질

4

반응물 1

HCID 86649157Tert-butyl (2-{4-[2-(1-adamantyl)ethoxy]phenyl}ethyl)-carbamate

생성물 1

HCID 67520640(2-{4-[2-(1-Adamantyl)ethoxy]phenyl}ethyl)amine

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 887Methanol용매

실험 절차

Obtained from Intermediate 21 (0.167 g, 1.42 mmol) in hydrogen chloride 1.25M in methanol by the same procedure described in Intermediate 17. The solvent was removed to give the title compound as a white solid salt (0.127 g, 98%), which was used in the next step without further purification. MS (M+): 300.

후처리

  1. customThe solvent was removed

출처 및 근거

ORD 기록
ord-d5fcafff68ed4960823637c5680dca13
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08178679B2

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