Hydrochloric Acid → N-(4-butyl-2-chlorophenyl)acetamide

HRID 1925712노트

반응식

HRID 1925712 반응식
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:14])[CH3:13])=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4].[Cl:15]N1C(=O)CCC1=O.Cl>CN(C)C=O>[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:14])[CH3:13])=[C:7]([Cl:15])[CH:6]=1)[CH2:2][CH2:3][CH3:4]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 31398ChlorosuccinimideHCID 77227Acetamide, N-(4-butylphenyl)-

생성물 1

HCID 59180380N-(4-butyl-2-chlorophenyl)acetamide수율 103.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
70 °C

실험 절차

A mixture of 67 (7.0 g; 36.6 mmol) and N-chlorosuccinimide (7.8 g; 58.6 mmol) was dissolved in N,N-dimethylformamide (70 mL). The reaction was heated at 70° C. for 6 hours, cooled to room temperature, then poured into aqueous hydrochloric acid (400 mL; 2M), and stirred for 15 minutes. The resulting precipitate was isolated by filtration and dried under vacuum to give the title product as an orange solid (8.54 g).

후처리

  1. temperaturecooled to room temperature
  2. customThe resulting precipitate was isolated by filtration
  3. customdried under vacuum

출처 및 근거

ORD 기록
ord-ad311ba304954a8f86fa6dafa422b20e
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08178699B2

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