Hydrochloric Acid → 5-(1-Piperidin-4-yl-1H-pyrazol-4-yl)-3-(7-trifluoromethoxy-isoquinolin-3-yl)-pyridin-2-ylamine trihydrochloride

온도

100 °C

A mixture of 4-{4-[6-amino-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-3-yl]-pyrazol-1-yl}-piperidine-1-carboxylic acid tert-butyl ester (BB3) (75 mg, 0.16 mmol), trifluoromethanesulfonic acid 7-trifluoromethoxyisoquinolin-3-yl ester (69 mg, 0.19 mmol), potassium carbonate (66 mg, 0.48 mmol), Pd(PPh3)4 (18 mg, 0.016 mmol) in DME (1.5 mL) and H2O (0.5 mL) was evacuated and refilled with N2 (3×), then it was heated at 100° C. for 30 min using the microwave reactor. The reaction mixture was diluted with EtOAc (30 mL), washed with brine (10 mL), and dried over anhydrous sodium sulfate. The residue was purified by silica gel chromatography (Hex.:EtOAc=30:70→15:85) to give a yellow solid. This material was dissolved in DCM (2 mL) and treated with 1M HCl in diethyl ether (3 mL). The resulting mixture was stirred at room temperature overnight. The title compound was collected by filtration as a yellow solid and washed with DCM. MS (ES+): m/z=455.12 [MH+].

1. customwas evacuated
2. additionrefilled with N2 (3×)
3. additionThe reaction mixture was diluted with EtOAc (30 mL)
4. washwashed with brine (10 mL)
5. dry with materialdried over anhydrous sodium sulfate
6. customThe residue was purified by silica gel chromatography (Hex.:EtOAc=30:70→15:85)
7. customto give a yellow solid
8. filtrationThe title compound was collected by filtration as a yellow solid
9. washwashed with DCM

ORD 기록

ord-cd55a761bce2442888ded348bf8c7d65

출처 데이터셋

uspto-grants-2012_05

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08178668B2