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1,1'-Carbonyldiimidazole → 5-(2,6-dioxopiperidin-3-yl)-5H-thieno(3,4-c)pyrrole-4,6-dione

HRID 1927135
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HRID 1927135 반응식
[C:1]1(=[O:10])[C:5]2=[CH:6][S:7][CH:8]=[C:4]2[C:3](=[O:9])O1.[NH2:11][CH:12]1[CH2:17][CH2:16][C:15](=[O:18])[NH:14][C:13]1=[O:19].C1N=CN(C(N2C=NC=C2)=O)C=1>C1COCC1.CN(C1C=CN=CC=1)C>[O:19]=[C:13]1[CH:12]([N:11]2[C:3](=[O:9])[C:4]3=[CH:8][S:7][CH:6]=[C:5]3[C:1]2=[O:10])[CH2:17][CH2:16][C:15](=[O:18])[NH:14]1
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참가 물질

6

반응물 3

HCID 682631,1'-CarbonyldiimidazoleHCID 1345083-Amino-2,6-piperidinedioneHCID 3156081H,3H-Thieno[3,4-c]furan-1,3-dione

생성물 1

HCID 597652875-(2,6-dioxopiperidin-3-yl)-5H-thieno(3,4-c)pyrrole-4,6-dione수율 79.5%

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매
HCID 8028
Tetrahydrofuran
용매

실험 절차

1.54 g thieno(3,4-c)furan-1,3-dione was dissolved in 20 mL of anhydrous THF, and 12.8 g of 3-aminopiperidine-2,6-dione was added. The reaction mixture was allowed to react at room temperature for 4 h. Then, 2 g of CDI and a catalytic quantity of DMAP were added, and the reaction mixture was allowed to reflux for 6 h until a large amount of white solid precipitated. The solid was cooled and filtered to yield 2.1 g of the title product.

후처리

  1. customto react at room temperature for 4 h
  2. temperatureto reflux for 6 h until a large amount of white solid
  3. customprecipitated
  4. temperatureThe solid was cooled
  5. filtrationfiltered

출처 및 근거

ORD 기록
ord-1b2657f672f14c0b92312f49f7f2d799
출처 데이터셋
uspto-grants-2012_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08183260B2

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