Tetrahydrofuran → (4-Benzyloxy-phenyl)-acetic acid hydrazide

HRID 1927230노트

반응식

HRID 1927230 반응식
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16](Cl)=[O:17])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1COCC1.C(N(CC)CC)C.O.[NH2:32][NH2:33]>O>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]([NH:32][NH2:33])=[O:17])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 24654Hydrazine hydrate (1:1)HCID 113574424-Benzyloxyphenylacetyl Chloride

생성물 1

HCID 59287387(4-Benzyloxy-phenyl)-acetic acid hydrazide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a mixture of 4-benzyloxyphenylacetyl chloride (1.1 g) and THF (10 mL) were added triethylamine (1.8 mL) and hydrazine hydrate (0.20 mL) at room temperature, which was stirred at the same temperature for 7.5 hours. Water was added to the reaction solution, which was then extracted with ethyl acetate, and the organic layer was washed with saturated brine. The solvent was evaporated under a reduced pressure, after which the residue was purified by silica gel chromatography (methanol:ethyl acetate=1:30) to obtain the titled compound (0.23 g).

후처리

  1. extractionwas then extracted with ethyl acetate
  2. washthe organic layer was washed with saturated brine
  3. customThe solvent was evaporated under a reduced pressure
  4. customafter which the residue was purified by silica gel chromatography (methanol:ethyl acetate=1:30)

출처 및 근거

ORD 기록
ord-7b8bdd7125be462fb8d8e4b34ad552ff
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08183264B2

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