Ethanol → (3-(5-Methyl-thiophen-2-ylmethyl)-phenyl)-methanol
반응식
C(O)C.[CH3:4][C:5]1[S:9][C:8]([CH2:10][C:11]2[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=2)[CH:14]=[O:15])=[CH:7][CH:6]=1.[BH4-].[Na+]>O>[CH3:4][C:5]1[S:9][C:8]([CH2:10][C:11]2[CH:12]=[C:13]([CH2:14][OH:15])[CH:16]=[CH:17][CH:18]=2)=[CH:7][CH:6]=1참가 물질
5
실험 절차
To a solution of ethanol (5.0 mL) and 3-(5-methyl-thiophen-2-ylmethyl)-benzaldehyde (350 mg) described in Manufacturing Example 52-2 was added sodium borohydride (120 mg), which was stirred for 10 minutes at room temperature. Water was added to the reaction solution, which was then extracted with ethyl acetate. The solvent was evaporated from the organic layer under a reduced pressure, and the residue was purified by silica gel chromatography (heptane:ethyl acetate=2:1) to obtain the titled compound (300 mg).
후처리
- extractionwas then extracted with ethyl acetate
- customThe solvent was evaporated from the organic layer under a reduced pressure
- customthe residue was purified by silica gel chromatography (heptane:ethyl acetate=2:1)
출처 및 근거
- ORD 기록
- ord-6b304798ff4a446cace12547705eb42e
- 출처 데이터셋
- uspto-grants-2012_05
- 특허 번호
- US08183264B2
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