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Phthalimide → HCID 69304319, 화합물

HRID 1927626
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HRID 1927626 반응식
[CH2:1]([N:3]([CH2:28][CH3:29])[C:4](=[O:27])[CH:5]([N:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:23]=[CH:22][C:21]([CH2:24]O)=[CH:20][C:19]=2[F:26])[CH2:14][CH2:13]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH3:2].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[C:49]1(=[O:59])[NH:53][C:52](=[O:54])[C:51]2=[CH:55][CH:56]=[CH:57][CH:58]=[C:50]12.N(C(OCC)=O)=NC(OCC)=O>C1COCC1>[O:54]=[C:52]1[C:51]2[C:50](=[CH:58][CH:57]=[CH:56][CH:55]=2)[C:49](=[O:59])[N:53]1[CH2:24][C:21]1[CH:22]=[CH:23][C:18]([N:15]2[CH2:14][CH2:13][N:12]([CH:5]([C:6]3[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=3)[C:4]([N:3]([CH2:28][CH3:29])[CH2:1][CH3:2])=[O:27])[CH2:17][CH2:16]2)=[C:19]([F:26])[CH:20]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 6809PhthalimideHCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 69304083N,N-Diethyl-2-[4-(2-fluoro-4-hydroxymethyl-phenyl)-piperazin-1-yl]-2-phenyl-acetamide

생성물 1

HCID 69304319HCID 69304319, 화합물수율 60.4%

시약·촉매·용매 1

HCID 8028
Tetrahydrofuran
용매

실험 절차

A solution of N,N-diethyl-2-[4-(2-fluoro-4-hydroxymethyl-phenyl)-piperazin-1-yl]-2-phenyl-acetamide (0.14 g, 0.362 mmol) in THF (3 mL) was added triphenylphosphine (96.5 mg), phthalimide (76.9 mg), and diethyl azodicarboxylate (50 μL), and the mixture stirred at rt. After 16 h, the solvent was removed and the residue purified on SiO2EtOAc/hexanes) to provide 115.5 mg of the title compound. MS (ESI): mass calcd. for C31H33FN4O3, 528.62. m/z found, 529.6 [M+H]+.

후처리

  1. customthe solvent was removed
  2. customthe residue purified on SiO2EtOAc/hexanes)

출처 및 근거

ORD 기록
ord-096015c799d04ce199fd8500daf09185
출처 데이터셋
uspto-grants-2012_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08183239B2

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