Phosphorus oxychloride → HCID 4504275, 화합물

HRID 1927815노트

반응식

HRID 1927815 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[NH:11][C:10](=O)[N:9]=2)=[CH:4][CH:3]=1.P(Cl)(Cl)([Cl:21])=O>>[Cl:21][C:10]1[N:9]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[N:11]=1

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 120794684-(4-Chlorophenyl)-6-(trifluoromethyl)pyrimidin-2-ol

생성물 1

HCID 4504275HCID 4504275, 화합물

실험 절차

The title compound was prepared from 4-(4-chloro-phenyl)-6-trifluoromethyl-1H-pyrimidin-2-one (6.96 g, 25.3 mmol) and phosphoryl chloride (80 mL) according to the general procedure I. Obtained as an off-white solid (7.35 g, 99%). MS (EI) 292.0 [(M)+]; mp 108° C.

출처 및 근거

ORD 기록
ord-496e731f028249c6ae9ad677d29782e4
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08183262B2

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