Phosphorus oxychloride → 2-Chloro-4-(2-fluoro-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine

HRID 1927852노트

반응식

HRID 1927852 반응식
[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[C:12]1[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[NH:15][C:14](=O)[N:13]=1.O=P(Cl)(Cl)[Cl:25]>>[Cl:25][C:14]1[N:13]=[C:12]([C:3]2[CH:4]=[CH:5][C:6]([C:8]([F:11])([F:10])[F:9])=[CH:7][C:2]=2[F:1])[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[N:15]=1

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 574686894-(2-Fluoro-4-trifluoromethyl-phenyl)-6-trifluoromethyl-1h-pyrimidin-2-one

생성물 1

HCID 574686882-Chloro-4-(2-fluoro-4-trifluoromethyl-phenyl)-6-trifluoromethyl-pyrimidine

실험 절차

The title compound was prepared from 4-(2-fluoro-4-trifluoromethyl-phenyl)-6-trifluoromethyl-1H-pyrimidin-2-one (9.84 g, 0.03 mol) and phosphoroxychloride (50 ml) according to the general procedure I. Obtained as a light yellow solid (9.99 g, 96%). MS (ISN) 341.2 [(M−H)−]; mp 47° C.

출처 및 근거

ORD 기록
ord-fc14e94d514b4d2d879405469f2d5535
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08183262B2

반응 노트

불러오는 중…