Ethyl orthoformate → 6-Tetrazol-1-yl-pyridin-3-ol
반응식
[N-:1]=[N+:2]=[N-:3].[Na+].C(OC([O:12][CH2:13][CH3:14])OCC)C.[NH2:15][C:16]1[N:21]=[CH:20]C(O)=[CH:18][CH:17]=1>CC(O)=O>[N:21]1([C:16]2[N:15]=[CH:14][C:13]([OH:12])=[CH:18][CH:17]=2)[CH:20]=[N:3][N:2]=[N:1]1참가 물질
5
반응 조건
- 온도
- 100 °C
실험 절차
NaN3 (2.89 g, 44 mmol) and triethylorthoformate (7.4 ml, 44 mmol) were added to commercially available 6-amino-pyridin-3-ol (3.5 g, 32 mmol) in AcOH (50 mL). The reaction mixture was heated to 100° C. for 1-3 hours. The reaction was cooled to room temperature and left to stand overnight. The precipitate was filtered, washed with EtOAc (150 mL) and dried in vacuo. The crude product was obtained as a beige solid and used in the next step without further purification.
후처리
- temperatureThe reaction was cooled to room temperature
- waitleft
- filtrationThe precipitate was filtered
- washwashed with EtOAc (150 mL)
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-e334b9dea03d4ab796ae954b007b83a0
- 출처 데이터셋
- uspto-grants-2012_05
- 특허 번호
- US08183381B2
반응 노트
불러오는 중…