Water → 4-Isopropoxy-1H-indole-2-carboxylic acid
반응식
C[O:2][C:3]([C:5]1[NH:6][C:7]2[C:12]([CH:13]=1)=[C:11]([O:14][CH:15]([CH3:17])[CH3:16])[CH:10]=[CH:9][CH:8]=2)=[O:4].[Li+].[OH-].O>C1COCC1>[CH:15]([O:14][C:11]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:12]=1[CH:13]=[C:5]([C:3]([OH:4])=[O:2])[NH:6]2)([CH3:17])[CH3:16]참가 물질
5
실험 절차
4-Isopropoxy-1H-indole-2-carboxylic acid methyl ester 76 (114 mg, 0.49 mmol) is dissolved in 5 ml of THF. A 2M-solution of LiOH in water (2.5 ml, 5 mmol) is added and the mixture is stirred for 48 hours. The solvent is then evaporated and the residue is partitioned between water and EtOAc. The water layer is acidified with HCl and extracted twice with EtOAc. The combined organic layers are washed with brine, dried over anhydrous sodium sulfate, filtered and evaporated to give a yellow powder.
후처리
- customThe solvent is then evaporated
- customthe residue is partitioned between water and EtOAc
- extractionextracted twice with EtOAc
- washThe combined organic layers are washed with brine
- dry with materialdried over anhydrous sodium sulfate
- filtrationfiltered
- customevaporated
- customto give a yellow powder
출처 및 근거
- ORD 기록
- ord-f861786c00bd466f9cdd107182df21bd
- 출처 데이터셋
- uspto-grants-2012_05
- 특허 번호
- US08183366B2
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