Bromine → 6-[1-(2,3-Dichloro-6-fluorophenyl)ethoxy]-5-fluoro-1,3-benzothiazol-2-amine
반응식
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[C:4]([F:9])[C:3]=1[CH:10]([O:12][C:13]1[CH:19]=[CH:18][C:16]([NH2:17])=[CH:15][C:14]=1[F:20])[CH3:11].[S-:21][C:22]#[N:23].[K+].BrBr>>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[C:4]([F:9])[C:3]=1[CH:10]([O:12][C:13]1[C:14]([F:20])=[CH:15][C:16]2[N:17]=[C:22]([NH2:23])[S:21][C:18]=2[CH:19]=1)[CH3:11]참가 물질
4
실험 절차
6-[1-(2,3-Dichloro-6-fluorophenyl)ethoxy]-5-fluoro-1,3-benzothiazol-2-amine was prepared according to the method described in Example 20d but from 2 g of 4-[1-(2,3-dichloro-6-fluorophenyl)ethoxy]-3-fluoroaniline, 2.44 g of potassium thiocyanate and 0.322 cm3 of dibromine. We obtain 2.3 g of 6-[1-(2,3-dichloro-6-fluorophenyl)ethoxy]-5-fluoro-1,3-benzothiazol-2-amine in the form of a cream-coloured powder, which has the following characteristics: