3,4-Dimethylphenol → HCID 13381509, 화합물
반응식
[CH3:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[CH3:8].C(=O)([O-])[O-].[K+].[K+].Br[CH2:17][C:18]([O:20][CH3:21])=[O:19]>CC(=O)CC>[CH3:21][O:20][C:18](=[O:19])[CH2:17][O:9][C:4]1[CH:5]=[CH:6][C:7]([CH3:8])=[C:2]([CH3:1])[CH:3]=1참가 물질
5
실험 절차
A mixture of 3,4-dimethyl-phenol (5.000 g; 40.928 mmol), potassium carbonate (7.070 g; 51.160 mmol), and methyl bromoacetate (4.70 ml; 51.160 mmol) in butanone (280 ml) was heated at reflux for 4 h. Filtration, concentration to dryness under reduced pressure, and purification by FC (heptane/EA, 4/1) afforded (3,4-dimethyl-phenoxy)-acetic acid methyl ester as a pale yellow oil (7.400 g; 93%). LC-MS: tR=0.92 min.; [M+H]+: no ionisation.
후처리
- temperaturewas heated
- temperatureat reflux for 4 h
- filtrationFiltration, concentration to dryness
- customunder reduced pressure, and purification by FC (heptane/EA, 4/1)
출처 및 근거
- ORD 기록
- ord-89769765d3aa4f58a34480477bce017c
- 출처 데이터셋
- uspto-grants-2012_05
- 특허 번호
- US08188082B2
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