Sodium Hydroxide → 3,4-Xylyloxyacetic acid
반응식
C[O:2][C:3](=[O:14])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH3:12])=[C:8]([CH3:13])[CH:7]=1.[OH-].[Na+]>CO>[CH3:13][C:8]1[CH:7]=[C:6]([CH:11]=[CH:10][C:9]=1[CH3:12])[O:5][CH2:4][C:3]([OH:14])=[O:2]참가 물질
4
실험 절차
A solution of (3,4-dimethyl-phenoxy)-acetic acid methyl ester (7.399 g; 38.099 mmol) in MeOH (100 ml) was treated with aq. 1N NaOH (57 ml; 1.5 eq.), and the resulting mixture was further stirred at rt for 30 min. MeOH was then removed under reduced pressure, water (100 ml) was added followed by aq. 1N HCl (75 ml). Filtration of the precipitated solid, and drying under HV afforded (3,4-dimethyl-phenoxy)-acetic acid as a colorless solid (6.070 g; 88%). LC-MS: tR=0.81 min.; [M+H]+: no ionisation.
후처리
- customMeOH was then removed under reduced pressure, water (100 ml)
- additionwas added
- filtrationFiltration of the precipitated solid
- customdrying under HV
출처 및 근거
- ORD 기록
- ord-57cb984dd9894486ba8706a5b5c2169e
- 출처 데이터셋
- uspto-grants-2012_05
- 특허 번호
- US08188082B2
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