Ammonium Acetate → 7-Bromo-6-fluoro-1,2-dihydroisoquinolin-1-one

HRID 1930219노트

반응식

HRID 1930219 반응식
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[C:9]2Cl)=[CH:4][C:3]=1[F:13].C([O-])(=[O:16])C.[NH4+]>C(O)(=O)C>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][NH:8][C:9]2=[O:16])=[CH:4][C:3]=1[F:13]

참가 물질

4

반응물 2

HCID 517165Ammonium AcetateHCID 598182627-Bromo-1-chloro-6-fluoroisoquinoline

생성물 1

HCID 598182537-Bromo-6-fluoro-1,2-dihydroisoquinolin-1-one수율 83%

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
100 °C

실험 절차

12.9 g (49.5 mmol) 7-bromo-1-chloro-6-fluoro-isoquinoline (311) were dissolved in 250 mL of acetic acid. After adding 38.7 g (0.5 mol) ammonium acetate, the solution was stirred at 100° C. After 3 h, the solvent was removed i. vac. and the residue was poured on water. The precipitate was filtered and dried to yield 9.91 g (83%) of the title compound. Rt=1.15 min (Method C). Detected mass: 242.2/244.1 (M+H+).

후처리

  1. customthe solvent was removed i
  2. additionand the residue was poured on water
  3. filtrationThe precipitate was filtered
  4. customdried

출처 및 근거

ORD 기록
ord-e59befaa23aa446cb0844059c8df8d73
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08188117B2

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