Hydrochloric Acid → HCID 178493227, 화합물

HRID 1930547

반응식

HRID 1930547 반응식
Cl.[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH:8]=[CH:9][C:10]=1[N:11]1[CH:15]=[C:14]([CH3:16])[N:13]=[CH:12]1)[NH2:7].[N:17]#[C:18][NH2:19].Cl.C(=O)([O-])[O-].[K+].[K+]>C(O)C.O>[CH3:2][O:3][C:4]1[CH:5]=[C:6]([NH:7][C:18]([NH2:19])=[NH:17])[CH:8]=[CH:9][C:10]=1[N:11]1[CH:15]=[C:14]([CH3:16])[N:13]=[CH:12]1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 9864CyanamideHCID 11430Potassium CarbonateHCID 674242353-Methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline hydrochloride

생성물 1

HCID 178493227HCID 178493227, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline hydrochloride (3 g, 12.52 mmol), cyanamide (0.684 g, 16.27 mmol) and hydrochloric acid (1.564 mL, 18.77 mmol) in ethanol (20 mL) were heated to reflux o.n. The reaction mixture was concentrated under reduced pressure before the resulting mixture was poured on a solution of potassium carbonate (1.730 g, 12.52 mmol) in water (60 mL) and left in refrigerator o.n. The formed carbonate-salt was filtered off, and dried in vacuum oven o.n. The solid was washed with several portions of DCM, dried and used as such in next step.

후처리

  1. temperatureto reflux o.n
  2. concentrationThe reaction mixture was concentrated under reduced pressure before the resulting mixture
  3. waitleft in refrigerator o.n
  4. filtrationThe formed carbonate-salt was filtered off
  5. customdried in vacuum oven o.n
  6. washThe solid was washed with several portions of DCM
  7. customdried

출처 및 근거

ORD 기록
ord-2a2d78d2c7014e86a895a016a0723b14
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08188101B2

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