1,1'-Carbonyldiimidazole → HCID 59333745, 화합물

HRID 1930701

반응식

HRID 1930701 반응식
N1([C:6]([N:8]2[CH:12]=[CH:11][N:10]=[CH:9]2)=[O:7])C=CN=C1.[O:13]1[CH2:17][CH2:16][CH2:15][CH:14]1[CH2:18][CH2:19]C(O)=O>ClCCl>[N:8]1([C:6](=[O:7])[CH2:19][CH2:18][CH:14]2[CH2:15][CH2:16][CH2:17][O:13]2)[CH:12]=[CH:11][N:10]=[CH:9]1

참가 물질

4

반응물 2

HCID 682631,1'-CarbonyldiimidazoleHCID 2631613-(Oxolan-2-yl)propanoic acid

생성물 1

HCID 59333745HCID 59333745, 화합물수율 100.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Di-(1H-imidazol-1-yl)methanone (0.554 g, 3.42 mmol) was added in small portions to a stirred solution of 3-(tetrahydrofuran-2-yl)propanoic acid (0.469 g, 3.25 mmol) in dichloromethane (3 mL) at room temperature under argon. The reaction mixture is stirred at room temperature for 2 hours. The mixture was washed twice with water, dried over MgSO4 and concentrated resulting a quantitative yield of 1-(1H-imidazol-1-yl)-3-(tetrahydrofuran-2-yl)propan-1-one (632 mg, 100%).

후처리

  1. washThe mixture was washed twice with water
  2. dry with materialdried over MgSO4
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-2cb04fbc9ad746529d70a437f4cdea17
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08188101B2

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