Sodium borohydride → (2-Fluoro-6-hydroxymethyl-4-trifluoromethyl-phenyl)-methanol

HRID 1930830노트

반응식

FC1C=C(C=C(C(F)(F)F)C=1)C(N(C(C)C)C(C)C)=O.[F:21][C:22]1[CH:30]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:28]=[C:27]2[C:23]=1[CH2:24][O:25][C:26]2=[O:35].[BH4-].[Na+]>>[F:21][C:22]1[CH:30]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:28]=[C:27]([CH2:26][OH:35])[C:23]=1[CH2:24][OH:25]

참가 물질

반응물 3

HCID 4311764Sodium borohydride

HCID 442031433-Fluoro-N,N-diisopropyl-5-trifluoromethyl-benzamide

HCID 577532554-Fluoro-6-trifluoromethyl-3H-isobenzofuran-1-one

생성물 1

HCID 57753663(2-Fluoro-6-hydroxymethyl-4-trifluoromethyl-phenyl)-methanol

실험 절차

Prepared in analogy to Example A16 (a) from 4-Fluoro-6-trifluoromethyl-3H-isobenzofuran-1-one e and sodium borohydride. Colorless oil. MS (m/e): 225.1 ([M+H+, 100%).

출처 및 근거

ORD 기록: ord-ba4200ef43c74c74aba42a094efa8463
출처 데이터셋: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08188139B2

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