Hydrochloric Acid → 5-Ethylsulfanyl-6-trifluoromethyl-2,3-dihydro-1H-isoindole hydrochloride

반응식

C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][C:12]([C:20]([F:23])([F:22])[F:21])=[C:13]([S:17][CH2:18][CH3:19])[CH:14]=2)[CH2:9]1)=O)(C)(C)C.[ClH:24]>>[ClH:24].[CH2:18]([S:17][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][C:12]=1[C:20]([F:23])([F:21])[F:22])[CH2:9][NH:8][CH2:16]2)[CH3:19]

참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 57753436HCID 57753436, 화합물

생성물 1

HCID 688216305-Ethylsulfanyl-6-trifluoromethyl-2,3-dihydro-1H-isoindole hydrochloride

실험 절차

Prepared in analogy to Example A3(e) from 5-ethylsulfanyl-6-trifluoromethyl-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester and hydrochloric acid. Yellow solid. MS (m/e): 284.3 ([M+H]+, 100%).

출처 및 근거

ORD 기록: ord-824efb1dd7d040288c53bdf6f019865d
출처 데이터셋: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08188139B2

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