Formamide → 5-Fluoroisoindoline-1,3-dione

반응식

[F:1][C:2]1[CH:3]=[C:4]2[C:9](=O)[O:8][C:6](=[O:7])[C:5]2=[CH:11][CH:12]=1.C([NH2:15])=O>>[F:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:11][CH:12]=1)[C:6](=[O:7])[NH:15][C:9]2=[O:8]

참가 물질

반응물 2

HCID 713Formamide

HCID 675721,3-Isobenzofurandione, 5-fluoro-

생성물 1

HCID 108990385-Fluoroisoindoline-1,3-dione수율 100%

반응 조건

온도: 200 °C

실험 절차

A mixture of 144 mmol 4-fluorophthalic anhydride and 1.16 mol formamide was heated at 200° C. for 2 h. The reaction mixture was poured onto ice-water and the resulting crystals collected by filtration and dried in vacuo to afford the title compound as a yellow solid (100% yield). MS (m/e): 164.4 ([M−H]−, 100%).

후처리

additionThe reaction mixture was poured onto ice-water
filtrationthe resulting crystals collected by filtration
customdried in vacuo

출처 및 근거

ORD 기록: ord-d7bd131a8df94912b0d2a22b005f80f4
출처 데이터셋: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08188139B2

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