Sodium Hydroxide → 3-[6-(2-Fluoro-phenyl)-pyridin-3-yl]-propionic acid

HRID 1931419노트

반응식

HRID 1931419 반응식
C([O:3][C:4](=[O:20])[CH2:5][CH2:6][C:7]1[CH:8]=[N:9][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[F:19])=[CH:11][CH:12]=1)C.[OH-].[Na+]>C(O)C>[F:19][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=1[C:10]1[N:9]=[CH:8][C:7]([CH2:6][CH2:5][C:4]([OH:20])=[O:3])=[CH:12][CH:11]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 68537058Ethyl 3-[6-(2-fluorophenyl)pyridin-3-yl]propanoate

생성물 1

HCID 685351183-[6-(2-Fluoro-phenyl)-pyridin-3-yl]-propionic acid

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
47.5 °C

실험 절차

11.5 g (0.042 mol) of 3-[6-(2-fluoro-phenyl)-pyridin-3-yl]-propionic acid ethyl ester were dissolved in 230 ml ethanol, 7.7 ml of a 32% sodium hydroxide solution were added, and the mixture stirred at 45 to 50° C. for 1 h. After evaporation to dryness, the remaining solid was taken up in 100 ml of water, the pH was adjusted to 2.5 to 3 with 2 N hydrochloric acid, and the precipitated product was filtered off with suction. The solid was rinsed with water and dried. Yield 10.0 g.

후처리

  1. customAfter evaporation to dryness
  2. filtrationthe precipitated product was filtered off with suction
  3. washThe solid was rinsed with water
  4. customdried

출처 및 근거

ORD 기록
ord-893de52d6fb14e1893939aa08c916282
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08188291B2

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