Sodium hydride → HCID 68536693, 화합물

HRID 1931459노트

반응식

HRID 1931459 반응식
[H-].[Na+].[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1.[C:17]([O:21][C:22](=[O:38])[CH2:23]OC1C=NC(C2C=CC=CC=2F)=CC=1)([CH3:20])([CH3:19])[CH3:18].C(OC(=O)CBr)(C)(C)C>CN(C=O)C>[C:17]([O:21][C:22](=[O:38])[CH2:23][O:16][C:13]1[CH:14]=[N:15][C:10]([C:7]2[CH:6]=[CH:5][C:4]([F:3])=[CH:9][CH:8]=2)=[CH:11][CH:12]=1)([CH3:20])([CH3:19])[CH3:18]

참가 물질

6

반응물 4

HCID 24758Sodium hydrideHCID 79177tert-Butyl bromoacetateHCID 463127886-(4-Fluorophenyl)pyridin-3-OLHCID 68536675[6-(2-Fluoro-phenyl)-pyridin-3-yloxy]-acetic acid tert-butyl ester

생성물 1

HCID 68536693HCID 68536693, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

119 mg (2.72 mmol) of sodium hydride (55% in mineral oil) were added to 430 mg (2.27 mmol) of 6-(4-fluoro-phenyl)-pyridin-3-ol (prepared analogously as described in Example 76(a) to (d)) in 10 ml of DMF, and the mixture was stirred at room temperature for 60 min. Then 532 mg (2.72 mmol) of bromoacetic acid tert-butyl ester were added, and the reaction mixture was stirred at room temperature for 3 h. After evaporation, water and ethyl acetate were added. The organic phase was separated, dried, and evaporated. Yield: 433 mg.

후처리

  1. customprepared analogously
  2. stirringthe reaction mixture was stirred at room temperature for 3 h
  3. customAfter evaporation, water and ethyl acetate
  4. additionwere added
  5. customThe organic phase was separated
  6. customdried
  7. customevaporated

출처 및 근거

ORD 기록
ord-fdd0f3aced614d0a8afb922b1ea14767
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08188291B2

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