Trifluoroacetic acid → 3-(3-Chloro-2-fluorophenyl)pyrrolidin-3-ol

HRID 1931877

반응식

HRID 1931877 반응식
[Cl:1][C:2]1[C:3]([F:21])=[C:4]([C:8]2([OH:20])[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9]2)[CH:5]=[CH:6][CH:7]=1.FC(F)(F)C(O)=O>ClCCl>[Cl:1][C:2]1[C:3]([F:21])=[C:4]([C:8]2([OH:20])[CH2:12][CH2:11][NH:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 67404349Tert-butyl 3-(3-chloro-2-fluorophenyl)-3-hydroxypyrrolidine-1-carboxylate

생성물 1

HCID 685157443-(3-Chloro-2-fluorophenyl)pyrrolidin-3-ol

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Preparation according to Preparation 2: tert-Butyl 3-(3-chloro-2-fluorophenyl)-3-hydroxypyrrolidin-1-carboxylate (4.42 g, 14 mmol), dichloromethane (100 mL), trifluoroacetic acid (10 mL). Stirred for 1 h. Yield: 2.24 g.

후처리

  1. customPreparation
  2. customaccording to Preparation 2

출처 및 근거

ORD 기록
ord-d6c04860c10a4623b05ff2051763510e
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08188301B2

연결된 노트

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