Water → 5-fluoropyridine-2-carboxylic Acid

HRID 1934360

반응식

HRID 1934360 반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:8])=[N:6][CH:7]=1.[Mn]([O-])(=O)(=O)=[O:10].[K+].[OH2:15]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([OH:10])=[O:15])=[N:6][CH:7]=1

참가 물질

4

반응물 3

HCID 962WaterHCID 516875Potassium PermanganateHCID 27628635-Fluoro-2-methylpyridine

생성물 1

HCID 27628765-fluoropyridine-2-carboxylic Acid수율 28%

실험 절차

To water (100 ml) were added 5-fluoro-2-methylpyridine (J. Med. Chem., 32, 1970(1989): 2.2 g, 20 mmol) and potassium permanganate (19.1 g, 120 mmol), and heated under reflux for 4 hours. The reaction mixture was filtrated and the filtrate was concentrated, acidified with KHSO4, extracted with ethyl acetate and the extract was dried over Na2SO4. The sol vent was evaporated to give the title compound (0.80 g; 28%).

후처리

  1. temperatureheated
  2. temperatureunder reflux for 4 hours
  3. filtrationThe reaction mixture was filtrated
  4. concentrationthe filtrate was concentrated
  5. extractionextracted with ethyl acetate
  6. dry with materialthe extract was dried over Na2SO4
  7. customThe sol vent was evaporated

출처 및 근거

ORD 기록
ord-159807f999c849d1a9a4d7e5ef5a5db9
출처 데이터셋
uspto-grants-2002_05
특허 번호
US06384033B1

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