Hydrazine hydrate (1:1) → (4-Chloro-3-methoxyphenyl)methanamine
반응식
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][N:7]2C(=O)C3=CC=CC=C3C2=O)=[CH:4][C:3]=1[O:20][CH3:21].O.NN>C(O)C>[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][NH2:7])=[CH:4][C:3]=1[O:20][CH3:21]참가 물질
4
실험 절차
To a solution of N-(4-chloro-3-methoxybenzyl)phthalimide (3.00 g) in ethanol (60 mL) was added hydrazine hydrate (2.62 mL), and the mixture was heated for an hour under reflux. The resulting precipitates were faltered off and the filtrate was evaporated in vacuo. The residue was partitioned between chloroform and an aqueous saturated sodium bicarbonate solution. The separated organic layer was washed with water and brine, dried over magnesium sulfate and evaporated in vacuo to give 4-chloro-3-methoxybenzylamine as a yellow oil (1.64 g).
후처리
- temperaturethe mixture was heated for an hour
- temperatureunder reflux
- customThe resulting precipitates
- customthe filtrate was evaporated in vacuo
- customThe residue was partitioned between chloroform
- washThe separated organic layer was washed with water and brine
- dry with materialdried over magnesium sulfate
- customevaporated in vacuo
출처 및 근거
- ORD 기록
- ord-9118fe18302f486b89b864aa13dfd805
- 출처 데이터셋
- uspto-grants-2002_05
- 특허 번호
- US06384080B1
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