Thionyl Chloride → 3-(4-Methoxyphenyl)-2-phenylpropionyl chloride

HRID 1935735

반응식

HRID 1935735 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH:10]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:11](O)=[O:12])=[CH:5][CH:4]=1.S(Cl)([Cl:22])=O>ClCCl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH:10]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:11]([Cl:22])=[O:12])=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 977393-(4-Methoxyphenyl)-2-phenylpropionic acid

생성물 1

HCID 111403233-(4-Methoxyphenyl)-2-phenylpropionyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3-(4-Methoxyphenyl)-2-phenylpropanoic acid (12.5 g, 0.049 mol) was converted to its acid chloride by treatment with thionyl chloride (8.2 ml) in dry dichloromethane (75 ml) at 40° C. Excess thionyl chloride and dichloromethane were evaporated off. The crude product was used in the next step without purification.

후처리

  1. customExcess thionyl chloride and dichloromethane were evaporated off
  2. customThe crude product was used in the next step without purification

출처 및 근거

ORD 기록
ord-8330fac80b4f466ab997698fb37b3886
출처 데이터셋
uspto-grants-2002_05
특허 번호
US06388090B2

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