Sodium Chloride → HCID 9807043, 화합물

HRID 1936286노트

반응식

HRID 1936286 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]([C:26]4[CH:27]=[N:28][C:29]([Cl:32])=[CH:30][CH:31]=4)([OH:25])[C:19]4[N:20]([CH3:24])[CH:21]=[N:22][CH:23]=4)[CH:16]=3)[NH:11][C:10](=[O:33])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[Na+].[Cl-].C(=O)([O-])[O-].[Cs+].[Cs+].Br[CH2:43][CH:44]1[CH2:46][CH2:45]1>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]([C:26]4[CH:27]=[N:28][C:29]([Cl:32])=[CH:30][CH:31]=4)([OH:25])[C:19]4[N:20]([CH3:24])[CH:21]=[N:22][CH:23]=4)[CH:16]=3)[N:11]([CH2:43][CH:44]3[CH2:46][CH2:45]3)[C:10](=[O:33])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1

참가 물질

6

반응물 4

HCID 5234Sodium ChlorideHCID 10796Cesium carbonateHCID 81503BromomethylcyclopropaneHCID 155378354-(3-chloro-phenyl)-6-[(6-chloro-pyridin-3-yl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-1H-quinolin-2-one

생성물 1

HCID 9807043HCID 9807043, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of the title compound of example 1, 4-(3-chloro-phenyl)-6-[(6-chloro-pyridin-3-yl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-1H-quinolin-2-one (100 mg, 0.210 mmol) in DMF (2 ml) were added NaCl (8 mg), cesium carbonate (Cs2CO3, 103 mg, 0.315 mmol) and (bromomethyl)cyclopropane (0.041 ml, 0.420 mmol). The reaction mixture was stirred at ambient temperature for 15 hours. Additional 0.041 ml) of (bromomethyl)cyclopropane and 100 mg of Cs2CO were added. The reaction mixture was heated at 60° C. for 1 hour after which time it was partitioned between CHCl3 and water. The organic layer was washed with brine, dried over MgSO4 and concentrated under vacuum to give the crude product. It was chromatographed on silica gel with MeOH-CHCl3—NH4OH (3:97:0) as eluents to afford the title compound as a white solid (25 mg, 22% yield).

출처 및 근거

ORD 기록
ord-8e7e1e7581f34292a511419a1e598dec
출처 데이터셋
uspto-grants-2002_05
특허 번호
US06388092B2

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