Calcium Sulfate → Amikacin

반응식

S([O-])([O-])(=O)=O.[Ca+2].[CH2:7]1[C@@H:12]([NH:13][C:14]([C@@H:16]([OH:20])[CH2:17][CH2:18][NH2:19])=[O:15])[C@H:11]([O:21][C@H:22]2[O:27][C@H:26]([CH2:28][OH:29])[C@@H:25]([OH:30])[C@H:24]([NH2:31])[C@H:23]2[OH:32])[C@@H:10]([OH:33])[C@H:9]([O:34][C@H:35]2[O:40][C@H:39]([CH2:41][NH2:42])[C@@H:38]([OH:43])[C@H:37]([OH:44])[C@H:36]2[OH:45])[C@H:8]1[NH2:46].OS(O)(=O)=O>>[CH2:7]1[C@@H:12]([NH:13][C:14]([C@@H:16]([OH:20])[CH2:17][CH2:18][NH2:19])=[O:15])[C@H:11]([O:21][C@H:22]2[O:27][C@H:26]([CH2:28][OH:29])[C@@H:25]([OH:30])[C@H:24]([NH2:31])[C@H:23]2[OH:32])[C@@H:10]([OH:33])[C@H:9]([O:34][C@H:35]2[O:40][C@H:39]([CH2:41][NH2:42])[C@@H:38]([OH:43])[C@H:37]([OH:44])[C@H:36]2[OH:45])[C@H:8]1[NH2:46]

참가 물질

반응물 2

HCID 24497Calcium Sulfate

HCID 5458175Amikacin Sulfate Salt

생성물 1

HCID 37768Amikacin

실험 절차

Calcium sulfate (1 g) is thoroughly mixed with 50 mg of chondroitin sulfate-amikacin (above) and 25 mg amikacin sulfate(1:2). Hyaluronic acid solution (0.6 ml, 2%) is added and the mixture handled as described in Example 1.

출처 및 근거

ORD 기록: ord-0be0ec0734f448bc90a134912bdc1d7f
출처 데이터셋: uspto-grants-2002_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06391336B1

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