Tetrahydrofuran → 3,5-Dihydroxy-1-adamantyl methacrylate

HRID 1936524

반응식

HRID 1936524 반응식
[C:1]12([OH:13])[CH2:10][C:5]3([OH:11])[CH2:6][CH:7]([CH2:9][C:3]([OH:12])([CH2:4]3)[CH2:2]1)[CH2:8]2.C(N(CC)CC)C.O1CCCC1.[C:26](Cl)(=[O:30])[C:27]([CH3:29])=[CH2:28]>O>[C:26]([O:13][C:1]12[CH2:10][C:5]3([OH:11])[CH2:6][CH:7]([CH2:9][C:3]([OH:12])([CH2:4]3)[CH2:2]1)[CH2:8]2)(=[O:30])[C:27]([CH3:29])=[CH2:28]

참가 물질

6

반응물 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 13528Methacryloyl chlorideHCID 98990221,3,5-Adamantanetriol

생성물 1

HCID 130073943,5-Dihydroxy-1-adamantyl methacrylate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

10 mmol of 1,3,5-adamantanetriol, 10 mmol of triethylamine, and 40 ml of tetrahydrofuran were mixed, and 10 mmol of methacrylic acid chloride was added dropwise to the mixture for about 30 minutes. After completion of the dropwise addition, the mixture was stirred at room temperature for 24 hours. After the reaction had been completed, to the reaction mixture was added water, followed by purification by column chromatography to give 1-methacryloyloxy-3,5-dihydroxyadamantane.

후처리

  1. additionAfter completion of the dropwise addition
  2. customfollowed by purification by column chromatography

출처 및 근거

ORD 기록
ord-117c406f89914498bb4879bfd9ee1c9f
출처 데이터셋
uspto-grants-2002_05
특허 번호
US06391520B1

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