Sodium Hydroxide → sodium [6,7,8,9-tetrahydro-6-[((2S)-2-hydroxy-3-phenoxypropyl)amino]-5H-benzocyclohepten-1-yloxy]acetate

HRID 1936972노트

반응식

HRID 1936972 반응식
C([O:3][C:4]([CH2:6][O:7][C:8]1[C:13]2[CH2:14][CH2:15][CH2:16][CH:17]([NH:19][CH2:20][C@H:21]([OH:30])[CH2:22][O:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:18][C:12]=2[CH:11]=[CH:10][CH:9]=1)=[O:5])C.[OH-].[Na+:32]>CO>[OH:30][C@H:21]([CH2:22][O:23][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)[CH2:20][NH:19][CH:17]1[CH2:16][CH2:15][CH2:14][C:13]2[C:8]([O:7][CH2:6][C:4]([O-:5])=[O:3])=[CH:9][CH:10]=[CH:11][C:12]=2[CH2:18]1.[Na+:32]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 70131462(2S)-1-[(1-ethoxycarbonylmethoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl)amino]-3-phenoxy-2-propanol

생성물 1

HCID 86584188sodium [6,7,8,9-tetrahydro-6-[((2S)-2-hydroxy-3-phenoxypropyl)amino]-5H-benzocyclohepten-1-yloxy]acetate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of (2S)-1-[(1-ethoxycarbonylmethoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl)amino]-3-phenoxy-2-propanol (103 mg) in methanol (5.0 ml) and 0.1N sodium hydroxide aqueous solution (2.5 ml) was stirred for 22 hours and evaporated in vacuo. The residue was triturated in diethyl ether and the precipitated powder was collected by filtration to afford sodium [6,7,8,9-tetrahydro-6-[((2S)-2-hydroxy-3-phenoxypropyl)amino]-5H-benzocyclohepten-1-yloxy]acetate (98 mg) as a pale yellow powder.

후처리

  1. customevaporated in vacuo
  2. customThe residue was triturated in diethyl ether
  3. filtrationthe precipitated powder was collected by filtration

출처 및 근거

ORD 기록
ord-ca2fdbd3cfa04b9db071205cd19d7277
출처 데이터셋
uspto-grants-2002_05
특허 번호
US06391915B2

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