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4-Iodophenol → 1-(4-Fluorophenyl)-3-(4-iodophenoxy)methyl-2-methyl-5-(4-methylsulfonylphenyl)pyrrole

HRID 1937358
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HRID 1937358 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][C:16]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:15][CH:14]=3)=[CH:11][C:10]([CH2:23][OH:24])=[C:9]2[CH3:25])=[CH:4][CH:3]=1.CCOC(/N=N/C(OCC)=O)=O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[I:57][C:58]1[CH:63]=[CH:62][C:61](O)=[CH:60][CH:59]=1>C1COCC1.O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][C:16]([S:19]([CH3:22])(=[O:20])=[O:21])=[CH:15][CH:14]=3)=[CH:11][C:10]([CH2:23][O:24][C:61]3[CH:62]=[CH:63][C:58]([I:57])=[CH:59][CH:60]=3)=[C:9]2[CH3:25])=[CH:6][CH:7]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 108944-IodophenolHCID 11776TriphenylphosphineHCID 5462977Diethyl azodicarboxylateHCID 105463821-(4-Fluorophenyl)-4-hydroxymethyl-5-methyl-2-(4-methylsulfonylphenyl)pyrrole

생성물 1

HCID 224606791-(4-Fluorophenyl)-3-(4-iodophenoxy)methyl-2-methyl-5-(4-methylsulfonylphenyl)pyrrole

시약·촉매·용매 2

HCID 962
Water
용매
HCID 8028Tetrahydrofuran용매

실험 절차

Compound 6 (from Example A) (1 mmol) is added to a solution of diethylazodicarboxylate (1 mmol), triphenylphosphine (1 mmol) and 4-iodophenol (1 mmol) in dry THF (25 mL). The progress of the reaction is monitored by tlc. When the reaction is complete, water is added and the crude product is extracted in ethyl acetate. The extract is dried and evaporated and the title compound 25 is purified by HPLC.

후처리

  1. extractionthe crude product is extracted in ethyl acetate
  2. customThe extract is dried
  3. customevaporated
  4. customthe title compound 25 is purified by HPLC

출처 및 근거

ORD 기록
ord-6d9cd3565f084a96b6b308e00ec90878
출처 데이터셋
uspto-grants-2002_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06395724B1

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