Hydrochloric Acid → 2-(Piperazin-1-yl)propan-1-ol dihydrochloride

HRID 1937419

반응식

HRID 1937419 반응식
[OH:1][CH2:2][CH:3]([N:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH:6]1C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[CH3:4].[ClH:30]>C(O)C.C(OCC)(=O)C>[ClH:30].[ClH:30].[OH:1][CH2:2][CH:3]([N:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)[CH3:4]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 54071300HCID 54071300, 화합물

생성물 1

HCID 119720442-(Piperazin-1-yl)propan-1-ol dihydrochloride수율 89%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8857Ethyl Acetate용매

실험 절차

1-(1-Hydroxy-2-propyl)-2-triphenylmethylpiperazine (1.69 g) obtained in step 2 was dissolved in ethanol (20 ml), and a 4 mol/l hydrogen chloride solution in ethyl acetate (10 ml) was dropwise added thereto. The mixture was stirred at room temperature for 10 minutes. The solvent was distilled off under reduced pressure, the residue was suspended in ethyl ether, and the precipitated crystals were collected by filtration to give Compound L (840 mg, 89%).

후처리

  1. distillationThe solvent was distilled off under reduced pressure
  2. filtrationthe precipitated crystals were collected by filtration

출처 및 근거

ORD 기록
ord-c8601b29fb4040a69dddd3603f032fcd
출처 데이터셋
uspto-grants-2002_05
특허 번호
US06395738B1

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