Methane → 2-(3-Chloro-phenoxy)-thiazole-4-carboxylic acid

HRID 1938142노트

반응식

HRID 1938142 반응식
C([O:3][C:4]([C:6]1[N:7]=[C:8]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=2)[S:9][CH:10]=1)=[O:5])C.[OH-].[Na+].C>O>[Cl:18][C:14]1[CH:13]=[C:12]([CH:17]=[CH:16][CH:15]=1)[O:11][C:8]1[S:9][CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=1

참가 물질

5

반응물 3

HCID 297MethaneHCID 14798Sodium HydroxideHCID 214686012-(3-Chloro-phenoxy)-thiazole-4-carboxylic acid ethyl ester

생성물 1

HCID 214686062-(3-Chloro-phenoxy)-thiazole-4-carboxylic acid수율 94.7%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
60 °C

실험 절차

A mixture of 26,36g (92.9 mmol) ethyl-2-(3-chlorophenoxy)thiazole-4-carboxylate (prepared analogously to the procedures of Example 1c), 7.5 g (187.5 mmol) NaOH and 300 ml of water was stirred 1 hour at 60° C. and 16 hours at room temperature. After adding a small amount of charcoal the yellow solution was stirred 10 minutes at room temperature and the charcoal separated by silica gel filtration. The filtrate was acidified with conc. HCl and the precipitate was collected and dried to give 22.5 g (94.7%) of 2-(3-chlorophenoxy)thiazole-4-carboxylic acid of m.p. 135°-137° C.

후처리

  1. stirringwas stirred 10 minutes at room temperature
  2. customthe charcoal separated by silica gel filtration
  3. customthe precipitate was collected
  4. customdried

출처 및 근거

ORD 기록
ord-9eeb861e785142f8b5a100dcaf7f3551
출처 데이터셋
uspto-grants-1997_12
특허 번호
US05693594

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