1,3,5-Trimethyl-4-nitro-1H-pyrazole → 1,3,5-trimethyl-1H-pyrazol-4-amine

HRID 1938679

반응식

HRID 1938679 반응식
[N+:1]([C:4]1[C:5]([CH3:11])=[N:6][N:7]([CH3:10])[C:8]=1[CH3:9])([O-])=O>[Ni].N>[NH2:1][C:4]1[C:5]([CH3:11])=[N:6][N:7]([CH3:10])[C:8]=1[CH3:9]

참가 물질

4

반응물 1

HCID 1210191,3,5-Trimethyl-4-nitro-1H-pyrazole

생성물 1

HCID 1616031,3,5-trimethyl-1H-pyrazol-4-amine

시약·촉매·용매 2

HCID 935Nickel촉매HCID 222Ammonia용매

실험 절차

The compounds from (b) above (2.3 g; 0.014 moles) was catalytically hydrogenated using Raney nickel (1 g) in methanolic ammonia (100 mL) under a hydrogen atmosphere at 50 psi. The catalyst was filtered and the solution concentrated in vacuo, leaving a residue that was triturated several times with ethyl ether. The decanted solvent was concentrated to dryness, leaving a pale red solid. Yield: 1.3 g (70%).

후처리

  1. filtrationThe catalyst was filtered
  2. concentrationthe solution concentrated in vacuo
  3. customleaving a residue that
  4. customwas triturated several times with ethyl ether
  5. concentrationThe decanted solvent was concentrated to dryness
  6. customleaving a pale red solid

출처 및 근거

ORD 기록
ord-7499a540f9324c048fff25eb22982f83
출처 데이터셋
uspto-grants-1997_12
특허 번호
US05693657

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