2-(6-(Cyanomethyl)pyridin-2-yl)acetonitrile → HCID 12131338, 화합물

HRID 1939874노트

반응식

HRID 1939874 반응식
[C:1]([CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][C:11]#[N:12])[N:5]=1)#[N:2]>CO.[Ni]>[NH2:2][CH2:1][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][CH2:11][NH2:12])[N:5]=1

참가 물질

4

반응물 1

HCID 5826922-(6-(Cyanomethyl)pyridin-2-yl)acetonitrile

생성물 1

HCID 12131338HCID 12131338, 화합물수율 83%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

To a solution of 2,6-bis(cyanomethyl)pyridine (4.3 g, 27 mmol) in methanol (75 ml, saturated with ammonia) was added Raney nickel (10.0 g, excess) and the mixture hydrogenated at 45 psi and room temperature for 48 hours. The catalyst was filtered off and the solvent evaporated in vacuo to give 2,6-bis(2-aminoethyl)pyridine as a brown viscous oil (3.7 g, 83%). This was used without further purification.

후처리

  1. filtrationThe catalyst was filtered off
  2. customthe solvent evaporated in vacuo

출처 및 근거

ORD 기록
ord-1ed6c26f3d85450ebdb7a193f29c0e46
출처 데이터셋
uspto-grants-1997_12
특허 번호
US05698546

반응 노트

불러오는 중…