2-Heptanol → (1-Methyl)hexyl 2-pyridyloxyacetate

HRID 1939877

반응식

HRID 1939877 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[O:7][CH2:8][C:9](OCC)=[O:10].[CH3:14][CH:15]([OH:21])[CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]>CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(C)[O-].[Ti+4]>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[O:7][CH2:8][C:9]([O:21][CH:15]([CH3:14])[CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=[O:10]

참가 물질

4

반응물 2

HCID 109762-HeptanolHCID 21464941Ethyl 2-(pyridin-2-yloxy)acetate

생성물 1

HCID 21464939(1-Methyl)hexyl 2-pyridyloxyacetate수율 90%

시약·촉매·용매 1

HCID 11026Titanium isopropoxide촉매

반응 조건

온도
120 °C

실험 절차

5.0 g (28 mmol) of ethyl 2-pyridyloxyacetate were suspended in 100 ml of 2-heptanol, 1 ml of titanium tetraisopropoxide were added, and the mixture was stirred for 4 hours at 120° C. The excess 2-heptanol was subsequently distilled off under an oil pump vacuum, and the residue was purified by column chromatography. 6.2 g (90% of theory) of (1-methyl)hexyl 2-pyridyloxyacetate were obtained as a colorless oil.

후처리

  1. distillationThe excess 2-heptanol was subsequently distilled off under an oil pump vacuum
  2. customthe residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-240782b943054781b8e440bec68b2785
출처 데이터셋
uspto-grants-1997_12
특허 번호
US05698539

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