(1,1'-Biphenyl)-4-carboxylic acid → (1,1'-Bi(cyclohexane))-4-carboxylic acid

HRID 1939885

반응식

HRID 1939885 반응식
[C:1]1([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:6]=[CH:5][C:4]([C:7]([OH:9])=[O:8])=[CH:3][CH:2]=1>C(O)C.CCOC(C)=O.[Rh]>[CH:10]1([CH:1]2[CH2:6][CH2:5][CH:4]([C:7]([OH:9])=[O:8])[CH2:3][CH2:2]2)[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]1

참가 물질

5

반응물 1

HCID 66724(1,1'-Biphenyl)-4-carboxylic acid

생성물 1

HCID 3062287(1,1'-Bi(cyclohexane))-4-carboxylic acid수율 93.5%

시약·촉매·용매 3

HCID 23948Rhodium촉매HCID 702Ethanol용매HCID 8857Ethyl Acetate용매

실험 절차

Reduce a solution of 4-biphenylcarboxylic acid (10 g) in ethanol (EtOH) (175 mL) and EtOAc (30 mL) over 5% rhodium/alumina (7 g) under H2 (60 psi) for 8 days. Filter the catalyst and concentrate the solution to obtain the title compound (9.92 g).

후처리

  1. filtrationFilter the catalyst
  2. concentrationconcentrate the solution

출처 및 근거

ORD 기록
ord-99b5569094014fa7afb6336024ea3b65
출처 데이터셋
uspto-grants-1997_12
특허 번호
US05698548

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