Benzyl Chloride → 4-Benzyloxybenzophenone

HRID 1939966

반응식

HRID 1939966 반응식
[OH:1][C:2]1[CH:15]=[CH:14][C:5]([C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.[CH2:16](Cl)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.C(=O)([O-])[O-].[K+].[K+]>[I-].[K+].CN(C)C=O>[CH2:16]([O:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:7])=[CH:14][CH:15]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

6

반응물 3

HCID 7503Benzyl ChlorideHCID 11430Potassium CarbonateHCID 143474-Hydroxybenzophenone

생성물 1

HCID 4581934-Benzyloxybenzophenone수율 99%

시약·촉매·용매 2

HCID 4875Potassium Iodide촉매HCID 6228Dimethylformamide용매

실험 절차

(60 g (0.3 mol) of 4-hydroxybenzophenone, 42 g of benzyl chloride, 45.6 g of potassium carbonate, 0.5 g of potassium iodide and 1 litre of dimethylformamide are introduced into a flask. Stirring is carried out at room temperature for 72 hours. The mixture is filtered and concentrated to dryness without exceeding 30° C. The residue is taken up in methylene chloride and washed with a 10% sodium carbonate solution and then with a saturated lithium chloride solution. The mixture is dried over sodium sulphate and concentrated to dryness. There are obtained 85 g of 4-benzyloxybenzophenone. Yield: 99%.

후처리

  1. filtrationThe mixture is filtered
  2. concentrationconcentrated to dryness
  3. customwithout exceeding 30° C
  4. washwashed with a 10% sodium carbonate solution
  5. dry with materialThe mixture is dried over sodium sulphate
  6. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-e7640f60fc474ab681608951ba56c907
출처 데이터셋
uspto-grants-1997_12
특허 번호
US05698567

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