7-(Trifluoroacetylamino)-2,3-dihydrobenzofuran → 2,3-Dihydro-1-benzofuran-7-amine

HRID 1940592노트

반응식

HRID 1940592 반응식
FC(F)(F)C([NH:5][C:6]1[C:14]2[O:13][CH2:12][CH2:11][C:10]=2[CH:9]=[CH:8][CH:7]=1)=O>CO.[OH-].[Na+]>[NH2:5][C:6]1[C:14]2[O:13][CH2:12][CH2:11][C:10]=2[CH:9]=[CH:8][CH:7]=1

참가 물질

4

반응물 1

HCID 214634927-(Trifluoroacetylamino)-2,3-dihydrobenzofuran

생성물 1

HCID 128059502,3-Dihydro-1-benzofuran-7-amine수율 96.2%

시약·촉매·용매 2

HCID 887Methanol용매HCID 14798Sodium Hydroxide용매

실험 절차

A solution of 7-(trifluoroacetylamino)-2,3-dihydrobenzofuran (D2) (1.6 g) in methanol (30 ml) and 10% NaOH (3 ml) was heated to reflux for 24h. The mixture was evaporated under reduced pressure and partitioned between ethyl acetate and water. The organic phase was dried (Na2SO4) and the solvent evaporated under reduced pressure to give the title compound (900 mg, 96%) as a pale orange oil, which crystallised on standing.

후처리

  1. temperatureto reflux for 24h
  2. customThe mixture was evaporated under reduced pressure
  3. custompartitioned between ethyl acetate and water
  4. dry with materialThe organic phase was dried (Na2SO4)
  5. customthe solvent evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-8a7f6292877d4ba6b73be4be91a8a92f
출처 데이터셋
uspto-grants-1997_12
특허 번호
US05700818

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