Hydrochloric Acid → 1-(2,3-Dihydro-7-benzofuranyl)ethanone

HRID 1940596노트

반응식

HRID 1940596 반응식
[O:1]1[C:5]2[C:6]([C:10]([OH:12])=O)=[CH:7][CH:8]=[CH:9][C:4]=2[CH2:3][CH2:2]1.[CH3:13][Li].Cl>C(OCC)C>[C:10]([C:6]1[C:5]2[O:1][CH2:2][CH2:3][C:4]=2[CH:9]=[CH:8][CH:7]=1)(=[O:12])[CH3:13]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 27950142,3-Dihydro-1-benzofuran-7-carboxylic acidHCID 178418348HCID 178418348, 화합물

생성물 1

HCID 106070731-(2,3-Dihydro-7-benzofuranyl)ethanone

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

To a cooled suspension of 2,3-dihydrobenzofuran-7-carboxylic acid (D1) (2 g) in dry diethyl ether (100 ml) was added dropwise under argon, methyllithium (16.2 ml of a 1.5M solution in diethyl ether). The mixture was stirred at room temperature for 18 h, added to 5N hydrochloric acid (50 ml) and extracted into ethyl acetate. The organic phase was washed with potassium carbonate, then water and dried (Na2SO4). The solvent was evaporated under reduced pressure to leave the title compound as a plate lemon solid (1.5 g, 76%)

후처리

  1. additionwas added dropwise under argon
  2. extractionextracted into ethyl acetate
  3. washThe organic phase was washed with potassium carbonate
  4. dry with materialwater and dried (Na2SO4)
  5. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-68ff1040be2647289c7f4d896aa4538a
출처 데이터셋
uspto-grants-1997_12
특허 번호
US05700818

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