Methanol → 3-(4,5,7-Trifluorobenzothiazol-2-yl)propionic acid

HRID 1940609

반응식

HRID 1940609 반응식
CO.[OH-].[Na+].[F:5][C:6]1[C:11]2[N:12]=[C:13]([CH2:15][CH2:16][C:17]([O:19]CC)=[O:18])[S:14][C:10]=2[C:9]([F:22])=[CH:8][C:7]=1[F:23]>O>[F:5][C:6]1[C:11]2[N:12]=[C:13]([CH2:15][CH2:16][C:17]([OH:19])=[O:18])[S:14][C:10]=2[C:9]([F:22])=[CH:8][C:7]=1[F:23]

참가 물질

5

반응물 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 21463563Ethyl 3-(4,5,7-trifluorobenzothiazol-2-yl)propionate

생성물 1

HCID 214635293-(4,5,7-Trifluorobenzothiazol-2-yl)propionic acid수율 85%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

To a mixture of methanol (8 ml), water (6 ml) and 2N sodium hydroxide (2 ml, 4 mmol) was added ethyl 3-(4,5,7-trifluorobenzothiazol-2-yl)propionate (1.1 g, 3.8 mmol) and the mixture was stirred for 15 min. at ambient temperature. The reaction solution was diluted with water and then extracted with ethyl acetate. The organic layer was washed with water, then dried and evaporated to yield a residue, which was recrystallized from hexane-isopropyl ether to give 3-(4,5,7-trifluorobenzothiazol-2-yl)propionic acid (840 mg, 85%) as colorless needles.

후처리

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with water
  3. customdried
  4. customevaporated
  5. customto yield a residue, which
  6. customwas recrystallized from hexane-isopropyl ether

출처 및 근거

ORD 기록
ord-ce24b89938924a28b11bba22ecc063e1
출처 데이터셋
uspto-grants-1997_12
특허 번호
US05700819

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